Searchable abstracts of presentations at key conferences in endocrinology

ea0090p151 | Pituitary and Neuroendocrinology | ECE2023

Novel provocation test with MDMA (“ecstasy’) reveals oxytocin deficiency as a new pituitary entity in patients with central diabetes insipidus – a randomized placebo-controlled trial

Atila Cihan , Holze Friederike , Murugesu Rakithan , Rommers Nikki , Hutter Nina , Varghese Nimmy , Clara Odilia Sailer , Eckert Anne , Heinrichs Markus , Liechti Matthias , Christ-Crain Mirjam

Introduction: Patients with arginine vasopressin deficiency (AVP-D), known as central diabetes insipidus (cDI), often report psychological symptoms such as heightened anxiety levels, difficulties describing emotions, and depressed mood despite adequate treatment with desmopressin. Given the anatomical proximity, disruptions of the hypothalamic-pituitary axis causing an AVP-D could also disturb the oxytocin (OXT) system. OXT regulates socio-emotional functioning, including fear...